High-throughput optical screening of cellular mechanotransduction

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

High-throughput optical screening of cellular mechanotransduction

We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics. These μCBs expose adherent cells to a microTsunami, a transient microscale burst o...

متن کامل

High-throughput screening for modulators of cellular contractile force.

When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signalling intermediates with poorly defined relationships to such a physiological endpoint. Using cellular force as the target, here we report a new screening technology and demonstrate its applications using ...

متن کامل

High-throughput Cellular-resolution in Vivo Vertebrate Screening

Due to its small size and optical transparency, zebrafish larvae are excellent vertebrate models to study human diseases in vivo. We previously developed a high throughput screening platform capable of handling, cellular-resolution imaging and optically manipulating zebrafish larvae. Here, we present new novel technologies to significantly increase the throughput of our screening platform by mu...

متن کامل

Cellular basis of mechanotransduction.

Physical forces, such as those due to gravity, are fundamental regulators of tissue development. To influence morphogenesis, mechanical forces must alter growth and function. Yet little is known about how cells convert mechanical signals into a chemical response. This presentation attempts to place the potential molecular mediators of mechanotransduction within the context of the structural com...

متن کامل

Nootropic Medicinal Plants; Evaluating Potent Formulation By Novelestic High throughput Pharmacological Screening (HTPS) Method

The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Photonics

سال: 2014

ISSN: 1749-4885,1749-4893

DOI: 10.1038/nphoton.2014.165